IUPUC Spatial Innovation Lab

During the summer of 2016 the IUPUC ME Division envi-sioned the concept of an “Imagineering Lab” based largely on academic makerspace concepts. Important sub-sections of the Imagineering Lab are its “Actualization Lab” (mecha-tronics, actuators, sensors, DAQ devices etc.) and a “Spatial Innovation Lab” (SIL) based on developing “dream stations” (computer work stations) equipped with exciting new tech-nology in intuitive 2D and 3D image creation and Virtual Reality (VR) technology. The objective of the SIL is to cre-ate a work flow converting intuitively created imagery to an-imation, engineering simulation and analysis and computer driven manufacturing interfaces. This paper discusses the challenges and methods being used to create a sustainable Spatial Innovation Lab

Use of Programmed Piezo Crystal Flexures for Economic Vapor Deposition of Parylene HT® on Unlimited Lengths of Magnet Wire

The electronics industry recognizes the need for high-temperature electronics (HTE) particularly for aerospace and geothermal applications. HTE is generally defined as robust operation in temperatures up to 300°C. A major constraint to HTE is high temperature magnet wire which is pervasive in electronic component windings and signal wire for sensors. The magnet wire constraint is caused by the temperature limits of the thin Polytetrafluoroethylene (PTFE) and Fluorinated Ethylene Propylene (FEP) coatings applied to HT magnet wire that limits the operating temperature to 220°C. [1], [2] There are coatings, particularly parylene-based coatings such as parylene HT®, that would greatly improve HT magnet wire, signal wire, and create the potential for subminiature thermocouple (TC) sensors; however, the slow vapor deposition process required to apply parylene is generally thought impractical for use in pore-free coating of long lengths of small diameter wire. For this research, experiments were first performed coating small diameter, wire product prototypes in standard batch vacuum chambers utilizing static fixtures. Finding this approach impractical we devised a new process utilizing a piezo-crystal electrodynamically actuated fixture of 14” diameter by 18” height that supports a web of one 24,500’ long, continuous small-diameter wire. A prototype dynamic fixture was built and a trial run successfully coated a 1500’ length of 0.005” diameter copper wire with Parylene HT®. This successful demonstration was the basis for a DOL Phase I SBIR to explore the feasibility of electrodynamically actuated devises that would synchronize horizontal and vertical actuation to drive horizontal motion to the wire web to enable a continuous reel-to-reel operation for parylene vapor deposition. This is discussed in future work

HIV infection is an independent risk factor for decreased 6-minute walk test distance.

BackgroundAmbulatory function predicts morbidity and mortality and may be influenced by cardiopulmonary dysfunction. Persons living with HIV (PLWH) suffer from a high prevalence of cardiac and pulmonary comorbidities that may contribute to higher risk of ambulatory dysfunction as measured by 6-minute walk test distance (6-MWD). We investigated the effect of HIV on 6-MWD.MethodsPLWH and HIV-uninfected individuals were enrolled from 2 clinical centers and completed a 6-MWD, spirometry, diffusing capacity for carbon monoxide (DLCO) and St. George's Respiratory Questionnaire (SGRQ). Results of 6-MWD were compared between PLWH and uninfected individuals after adjusting for confounders. Multivariable linear regression analysis was used to determine predictors of 6-MWD.ResultsMean 6-MWD in PLWH was 431 meters versus 462 in 130 HIV-uninfected individuals (p = 0.0001). Older age, lower forced expiratory volume (FEV1)% or lower forced vital capacity (FVC)%, and smoking were significant predictors of decreased 6-MWD in PLWH, but not HIV-uninfected individuals. Lower DLCO% and higher SGRQ were associated with lower 6-MWD in both groups. In a combined model, HIV status remained an independent predictor of decreased 6-MWD (Mean difference = -19.9 meters, p = 0.005).ConclusionsHIV infection was associated with decreased ambulatory function. Airflow limitation and impaired diffusion capacity can partially explain this effect. Subjective assessments of respiratory symptoms may identify individuals at risk for impaired physical function who may benefit from early intervention

Spatially targeted nature-based solutions can mitigate climate change and nature loss but require a systems approach

Funding Information: This study was funded by the Royal Society for the Protection of Birds (RSPB) and Natural England (project code ECM 58632). The Breeding Bird Survey is a Partnership between the BTO, RSPB, and Joint Nature Conservation Committee (on behalf of Natural Resources Wales, Natural England, Council for Nature Conservation and Countryside, and NatureScot) and relies on volunteer surveyors. Simon Gillings provided tetrad-level predictions of relative abundance for wading birds. We are grateful to members of the RSPB steering group, who contributed to the development of our scenarios, and Profs. Tim Benton and Andrew Balmford who commented on an earlier version of this manuscript. Conceptualization, T.F. R.B.B. T.B.-L. G.M.B. W.J.P. and R.H.F.; methodology, T.F. T.B.-L. J.P.C. D.M. P.S. and R.H.F.; software, T.F.; formal analysis, T.F.; resources, D.M.; data curation, T.F.; writing – original draft, T.F.; writing – review & editing, R.B.B. T.B.-L. G.M.B. J.P.C. D.M. P.S. W.J.P. and R.H.F.; visualization, T.F.; supervision, W.J.P. The authors declare no competing interests. Publisher Copyright: © 2023 The AuthorsPeer reviewedPublisher PD

Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study

INTRODUCTION: Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population. METHODS: Population-based surveillance was conducted among all adult residents of the Calgary Health Region (population 1 million) admitted to multidisciplinary and cardiovascular surgical intensive care units between May 1 1999 and April 30 2002. Clinical records were reviewed and outcome at 1 year was assessed. RESULTS: sARF occurred in 240 patients (11.0 per 100,000 population/year). Rates were highest in males and older patients (≥65 years of age). Risk factors for development of sARF included previous heart disease, stroke, pulmonary disease, diabetes mellitus, cancer, connective tissue disease, chronic renal dysfunction, and alcoholism. The annual mortality rate was 7.3 per 100,000 population with rates highest in males and those ≥65 years. The 28-day, 90-day, and 1-year case-fatality rates were 51%, 60%, and 64%, respectively. Increased Charlson co-morbidity index, presence of liver disease, higher APACHE II score, septic shock, and need for continuous renal replacement therapy were independently associated with death at 1 year. Renal recovery occurred in 78% (68/87) of survivors at 1 year. CONCLUSION: sARF is common and males, older patients, and those with underlying medical conditions are at greatest risk. Although the majority of patients with sARF will die, most survivors will become independent from renal replacement therapy within a year

Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra

BACKGROUND: Recent attention has focused on understanding the role of the brain-renin-angiotensin-system (RAS) in stroke and neurodegenerative diseases. Direct evidence of a role for the brain-RAS in Parkinson's disease (PD) comes from studies demonstrating the neuroprotective effect of RAS inhibitors in several neurotoxin based PD models. In this study, we show that an antagonist of the angiotensin II (Ang II) type 1 (AT(1)) receptor, losartan, protects dopaminergic (DA) neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity both in primary ventral mesencephalic (VM) cultures as well as in the substantia nigra pars compacta (SNpc) of C57BL/6 mice (Fig. 1). RESULTS: In the presence of exogenous Ang II, losartan reduced MPP(+ )(5 μM) induced DA neuronal loss by 72% in vitro. Mice challenged with MPTP showed a 62% reduction in the number of DA neurons in the SNpc and a 71% decrease in tyrosine hydroxylase (TH) immunostaining of the striatum, whereas daily treatment with losartan lessened MPTP-induced loss of DA neurons to 25% and reduced the decrease in striatal TH(+ )immunostaining to 34% of control. CONCLUSION: Our study demonstrates that the brain-RAS plays an important neuroprotective role in the MPTP model of PD and points to AT(1 )receptor as a potential novel target for neuroprotection

The Grizzly, October 25, 1985

Registration has Come Upon Us • RA Supervision Allows Reimert\u27s Co-ed Transition • Siblings Sharing the Same Experience • One Hundred Years of Tradition Passes With Fretz • Prof. Profile: Armstrong Balances his own Studies With Students\u27 Studies • In Search of Success: Lehman Leans Towards Stockbroker • Letters: What is That Eye Material?; Walter Still Upset; Music Comes to UC • Scram Leaves its Name in Reimert History • Concert Review: Bon Jovi and Ratt Draw a Crowd of Leather • Wanted: Attempted Murder • Bears Fall to Fifth Ranked Gettysburg • Annual Snell Game Ends in a Tie • Booters Win a Big One Over Haverford Squad • Mers Ready to Plunge Into Season • New Course at U.C.: Human Sexuality • Richter Named as Chairman • How to Handle the Effects of Harmful Stress • Roving Reporter: Do You Think Fraternities and Sororities are a Positive Aspect of Campus Life?https://digitalcommons.ursinus.edu/grizzlynews/1149/thumbnail.jp

The Grizzly, October 18, 1985

Limerick: The Main Objective - Calm • Typesetting Equipment Offers New Experience • Letters: Ex-Rover Responds; Some Housing Needs Help; Reply for Sluggo • Financial Aid Striving to the Top • Search of Success Finds Bravo • Look Out for the Candid Cameras • Sorority Pledging Sees Light Through Tunnel • Field Hockey Battles Tough Competition • Booters Find Easier Times • Ultimate Frisbee is Here • Doleniak: Flying Higher Through the Sky • Grizzlies are Defeated • Campus Security Noteshttps://digitalcommons.ursinus.edu/grizzlynews/1148/thumbnail.jp

Individual Exposure to NO2 in Relation to Spatial and Temporal Exposure Indices in Stockholm, Sweden: The INDEX Study

Epidemiology studies of health effects from air pollution, as well as impact assessments, typically rely on ambient monitoring data or modelled residential levels. The relationship between these and personal exposure is not clear. To investigate personal exposure to NO2 and its relationship with other exposure metrics and time-activity patterns in a randomly selected sample of healthy working adults (20–59 years) living and working in Stockholm. Personal exposure to NO2 was measured with diffusive samplers in sample of 247 individuals. The 7-day average personal exposure was 14.3 µg/m3 and 12.5 µg/m3 for the study population and the inhabitants of Stockholm County, respectively. The personal exposure was significantly lower than the urban background level (20.3 µg/m3). In the univariate analyses the most influential determinants of individual exposure were long-term high-resolution dispersion-modelled levels of NO2 outdoors at home and work, and concurrent NO2 levels measured at a rural location, difference between those measured at an urban background and rural location and difference between those measured in busy street and at an urban background location, explaining 20, 16, 1, 2 and 4% (R2) of the 7-day personal NO2 variation, respectively. A regression model including these variables explained 38% of the variation in personal NO2 exposure. We found a small improvement by adding time-activity variables to the latter model (R2 = 0.44). The results adds credibility primarily to long-term epidemiology studies that utilise long-term indices of NO2 exposure at home or work, but also indicates that such studies may still suffer from exposure misclassification and dilution of any true effects. In contrast, urban background levels of NO2 are poorly related to individual exposure

The Structure of Episodic Memory: Ganeri's ‘Mental Time Travel and Attention’

We offer a framework for assessing what the structure of episodic memory might be, if one accepts the Buddhist denial of persisting selves. This paper is a response to Jonardon Ganeri's paper "Mental time travel and attention", which explores Buddhaghosa's ideas about memory. (It will eventually be published with a reply by Ganeri)